Structure of PDB 2f8s Chain A Binding Site BS01

Receptor Information
>2f8s Chain A (length=704) Species: 63363 (Aquifex aeolicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEALLNLYRIEYRPKDTTFTVFKPTHEIQKEKLNKVRWRVFLQTGLPTFR
REDEFWCAGKVEKDTLYLTLSNGEIVELKRVGEEEFRGFQNERECQELFR
DFLTKTKVKDKFISDFYKKFRDKITVQGKNRKIALIPEVNEKVLKSEEGY
FLLHLDLKFRIQPFETLQTLLERNDFNPKRIRVKPIGIDFVGRVQDVFKA
KEKGEEFFRLCMERSTHKSSKKAWEELLKNRELREKAFLVVLEKGYTYPA
TILKPVLTYENLEDEERNEVADIVRMEPGKRLNLIRYILRRYVKALRDYG
WYISPEEERAKGKLNFKDTVLDAKGKNTKVITNLRKFLELCRPFVKKDVL
SVEIISVSVYKKLEWRKEEFLKELINFLKNKGIKLKIKGKSLILAQTREE
AKEKLIPVINKIKDVDLVIVFLEEYPKVDPYKSFLLYDFVKRELLKKMIP
SQVILNRTLKNENLKFVLLNVAEQVLAKTGNIPYKLKEIEGKVDAFVGID
ISRITRDGKTVNAVAFTKIFNSKGELVRYYLTSYPAFGEKLTEKAIGDVF
SLLEKLGFKKGSKIVVHRDGRLYRDEVAAFKKYGELYGYSLELLEIIKRN
NPRFFSNEKFIKGYFYKLSEDSVILATYNQVYEGTHQPIKVRKVYGELPV
EVLCSQILSLTLMNYSSFQPIKLPATVHYSDKITKLMLRGIEPIKKEGDI
MYWL
Ligand information
>2f8s Chain C (length=22) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agacagcauauaugcugucuuu
......................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2f8s A Potential Protein-RNA Recognition Event along the RISC-Loading Pathway from the Structure of A. aeolicus Argonaute with Externally Bound siRNA.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		D112 I115 Y119 R123 I138 I188 G189 I190 D191 K256
Binding residue
(residue number reindexed from 1)		D110 I113 Y117 R121 I136 I186 G187 I188 D189 K254
Enzymatic activity
Enzyme Commision number 3.1.26.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004521 RNA endonuclease activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:2f8s, PDBe:2f8s, PDBj:2f8s
PDBsum2f8s
PubMed17027504
UniProtO67434|AGO_AQUAE Protein argonaute (Gene Name=ago)

[Back to BioLiP]