Structure of PDB 2f6x Chain A Binding Site BS01

Receptor Information
>2f6x Chain A (length=231) Species: 2234 (Archaeoglobus fulgidus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRWRKWRHITKLDPDRTNTDEIIKAVADSGTDAVMISGTQNVTYEKARTL
IEKVSQYGLPIVVEPSDPSNVVYDVDYLFVPTVLNSADGDWITGKHAQWV
RMHYENLQKFTEIIESEFIQIEGYIVLNPDSAVARVTKALCNIDKELAAS
YALVGEKLFNLPIIYIEYSGTYGNPELVAEVKKVLDKARLFYGGGIDSRE
KAREMLRYADTIIVGNVIYEKGIDAFLETLP
Ligand information
Ligand ID1GP
InChIInChI=1S/C3H9O6P/c4-1-3(5)2-9-10(6,7)8/h3-5H,1-2H2,(H2,6,7,8)/t3-/m0/s1
InChIKeyAWUCVROLDVIAJX-VKHMYHEASA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C(COP(=O)(O)O)O)O
OpenEye OEToolkits 1.5.0C([C@@H](COP(=O)(O)O)O)O
ACDLabs 10.04O=P(O)(O)OCC(O)CO
CACTVS 3.341OC[CH](O)CO[P](O)(O)=O
CACTVS 3.341OC[C@H](O)CO[P](O)(O)=O
FormulaC3 H9 O6 P
NameSN-GLYCEROL-1-PHOSPHATE
ChEMBL
DrugBank
ZINCZINC000003830895
PDB chain2f6x Chain A Residue 3001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2f6x The crystal structure of (S)-3-O-geranylgeranylglyceryl phosphate synthase reveals an ancient fold for an ancient enzyme
Resolution2.0 Å
Binding residue
(original residue number in PDB)		K1011 Y1165 E1167 G1193 G1194 G1195 G1215 N1216
Binding residue
(residue number reindexed from 1)		K11 Y165 E167 G193 G194 G195 G215 N216
Annotation score5
Enzymatic activity
Enzyme Commision number 2.5.1.41: phosphoglycerol geranylgeranyltransferase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0002094 polyprenyltransferase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0046872 metal ion binding
GO:0047294 phosphoglycerol geranylgeranyltransferase activity
Biological Process
GO:0006650 glycerophospholipid metabolic process
GO:0008654 phospholipid biosynthetic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2f6x, PDBe:2f6x, PDBj:2f6x
PDBsum2f6x
PubMed16377641
UniProtO29844|GGGPS_ARCFU Geranylgeranylglyceryl phosphate synthase (Gene Name=AF_0403)

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