Structure of PDB 2f54 Chain A Binding Site BS01
Receptor Information
>2f54 Chain A (length=274) Species:
9606
(Homo sapiens) [
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GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAP
WIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGYYNQSEAGSHTVQRMYG
CDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMAAQTTKHKWEAA
HVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEAT
LRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVP
SGQEQRYTCHVQHEGLPKPLTLRW
Ligand information
>2f54 Chain C (length=9) Species:
9606
(Homo sapiens) [
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SLLMWITQC
Receptor-Ligand Complex Structure
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PDB
2f54
Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.
Resolution
2.7 Å
Binding residue
(original residue number in PDB)
Y7 E63 K66 V67 H70 V76 D77 L81 Y84 Y99 T143 K146 W147 Y159 W167 Y171
Binding residue
(residue number reindexed from 1)
Y7 E63 K66 V67 H70 V76 D77 L81 Y84 Y99 T143 K146 W147 Y159 W167 Y171
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:2f54
,
PDBe:2f54
,
PDBj:2f54
PDBsum
2f54
PubMed
16600963
UniProt
P04439
|HLAA_HUMAN HLA class I histocompatibility antigen, A alpha chain (Gene Name=HLA-A)
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