Structure of PDB 2exf Chain A Binding Site BS01

Receptor Information
>2exf Chain A (length=44) Species: 11678 (Human immunodeficiency virus type 1 BH10) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NVKCFNCGKEGHTARNCRAPRKKGCWKCGKEGHQMKDCTERQAN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2exf How the HIV-1 nucleocapsid protein binds and destabilises the (-)primer binding site during reverse transcription.
ResolutionN/A
Binding residue
(original residue number in PDB)		N12 V13 K14 F16 G22 T24 R26 N27 R32 K34 G35 C36 W37 Q45 M46 K47
Binding residue
(residue number reindexed from 1)		N1 V2 K3 F5 G11 T13 R15 N16 R21 K23 G24 C25 W26 Q34 M35 K36
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:2exf, PDBe:2exf, PDBj:2exf
PDBsum2exf
PubMed18773912
UniProtP03366|POL_HV1B1 Gag-Pol polyprotein (Gene Name=gag-pol)

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