Structure of PDB 2ew7 Chain A Binding Site BS01

Receptor Information
>2ew7 Chain A (length=163) Species: 210 (Helicobacter pylori) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALLEIIHYPSKILRTISKEVVSFDAKLHQQLDDMYETMIASEGIGLAAIQ
VGLPLRMLIINLPQEDGVQHKEDCLEIINPKFIETGGSMMYKEGCLSVPG
FYEEVERFEKVKIEYQNRFAEVKVLEASELLAVAIQHEIDHLNGVLFVDK
LSILKRKKFEKEL
Ligand information
Ligand IDCO
InChIInChI=1S/Co/q+2
InChIKeyXLJKHNWPARRRJB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Co+2]
CACTVS 3.341[Co++]
FormulaCo
NameCOBALT (II) ION
ChEMBL
DrugBankDB14205
ZINC
PDB chain2ew7 Chain A Residue 300 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2ew7 Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation
Resolution2.2 Å
Binding residue
(original residue number in PDB)		Q51 C96 H138 H142
Binding residue
(residue number reindexed from 1)		Q50 C95 H137 H141
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) G46 Q51 C96 L97 H138 E139 H142
Catalytic site (residue number reindexed from 1) G45 Q50 C95 L96 H137 E138 H141
Enzyme Commision number 3.5.1.88: peptide deformylase.
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0042586 peptide deformylase activity
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0018206 peptidyl-methionine modification

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Molecular Function
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Biological Process
External links
PDB RCSB:2ew7, PDBe:2ew7, PDBj:2ew7
PDBsum2ew7
PubMed16882991
UniProtQ672W7

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