Structure of PDB 2ew1 Chain A Binding Site BS01

Receptor Information

>2ew1 Chain A (length=171) Species: 9606 (Homo sapiens)

DYDFLFKIVLIGNAGVGKTCLVRRFTQGLFPPGQGATIGVDFMIKTVEIN
GEKVKLQIWDTAGQERFRSITQSYYRSANALILTYDITCEESFRCLPEWL
REIEQYASNKVITVLVGNKIDLAERREVSQQRAEEFSEAQDMYYLETSAK
ESDNVEKLFLDLACRLISEAR

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 2ew1 Chain A Residue 701

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2ew1 Crystal structure of RAB30 in complex with a GTP analogue
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): T22 T40
• Binding residue (residue number reindexed from 1): T19 T37
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): V25 Q67
• Catalytic site (residue number reindexed from 1): V22 Q64

Gene Ontology

Molecular Function

• GO:0003924 GTPase activity
• GO:0005515 protein binding
• GO:0005525 GTP binding

Biological Process

• GO:0007030 Golgi organization
• GO:0016192 vesicle-mediated transport
• GO:0032482 Rab protein signal transduction

Cellular Component

• GO:0000139 Golgi membrane
• GO:0005737 cytoplasm
• GO:0005794 Golgi apparatus
• GO:0005795 Golgi stack
• GO:0005801 cis-Golgi network
• GO:0005802 trans-Golgi network
• GO:0016020 membrane
• GO:0031985 Golgi cisterna
• GO:0043231 intracellular membrane-bounded organelle

External links

• PDB: RCSB:2ew1, PDBe:2ew1, PDBj:2ew1
• PDBsum: 2ew1
• UniProt: Q15771|RAB30_HUMAN Ras-related protein Rab-30 (Gene Name=RAB30)