Structure of PDB 2etj Chain A Binding Site BS01

Receptor Information
>2etj Chain A (length=211) Species: 2336 (Thermotoga maritima) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MGIDELYKKEFGIVAGVDEAGRGCLAGPVVAAAVVLEKEIEAKRERLLDE
IMEKAAVGIGIASPEEIDLYNIFNATKLAMNRALENLSVKPSFVLVDGKG
IELSVPGTCLVKGDQKSKLIGAASIVAKVFRDRLMSEFHRMYPQFSFHKH
KGYATKEHLNEIRKNGVLPIHRLSFEPVLELLTDDLLREFFEKGLISENR
FERILNLLGAR
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain2etj Chain A Residue 239 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2etj Crystal structure of Ribonuclease HII (EC 3.1.26.4) (RNase HII) (tm0915) from THERMOTOGA MARITIMA at 1.74 A resolution
Resolution1.74 Å
Binding residue
(original residue number in PDB)
D18 D107
Binding residue
(residue number reindexed from 1)
D18 D97
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.26.4: ribonuclease H.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006298 mismatch repair
GO:0006401 RNA catabolic process
GO:0043137 DNA replication, removal of RNA primer
Cellular Component
GO:0005737 cytoplasm
GO:0032299 ribonuclease H2 complex

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:2etj, PDBe:2etj, PDBj:2etj
PDBsum2etj
PubMed
UniProtQ9X017|RNH2_THEMA Ribonuclease HII (Gene Name=rnhB)

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