Structure of PDB 2ehb Chain A Binding Site BS01

Receptor Information

>2ehb Chain A (length=182) Species: 3702 (Arabidopsis thaliana)

DPELLASVTPFTVEEVEALYELFKKLSSSIIDDGLIHKEEFQLALFRNRN
RRNLFADRIFDVFDVKRNGVIEFGEFVRSLGVFHPSAPVHEKVKFAFKLY
DLRQTGFIEREELKEMVVALLHESELVLSEDMIEVMVDKAFVQADRKNDG
KIDIDEWKDFVSLNPSLIKNMTLPYLKDINRT

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 2ehb Chain A Residue 1001

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2ehb The structure of the C-terminal domain of the protein kinase AtSOS2 bound to the calcium sensor AtSOS3
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): S46 I50 D52 L54 E59
• Binding residue (residue number reindexed from 1): S27 I31 D33 L35 E40
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0004723 calcium-dependent protein serine/threonine phosphatase activity
• GO:0005509 calcium ion binding
• GO:0005515 protein binding
• GO:0019900 kinase binding

Biological Process

• GO:0005513 detection of calcium ion
• GO:0019722 calcium-mediated signaling
• GO:0030007 intracellular potassium ion homeostasis
• GO:0042539 hypotonic salinity response

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005886 plasma membrane
• GO:0005955 calcineurin complex

External links

• PDB: RCSB:2ehb, PDBe:2ehb, PDBj:2ehb
• PDBsum: 2ehb
• PubMed: 17499048
• UniProt: O81223|CNBL4_ARATH Calcineurin B-like protein 4 (Gene Name=CBL4)