Structure of PDB 2e5a Chain A Binding Site BS01

Receptor Information

>2e5a Chain A (length=329) Species: 9913 (Bos taurus)

GLILQSISNDVYHNLAVEDWIHDHMNLEGKPVLFLWRNSPTVVIGRHQNP
WQECNLNLMREEGVKLARRRSGGGTVYHDMGNINLTFFTTKKKYDRMENL
KLVVRALKAVHPHLDVQATKRFDLLLDGQFKISGTASKIGRNAAYHHCTL
LCGTDGTFLSSLLKSPYQGIRSNATASTPALVKNLMEKDPTLTCEVVINA
VATEYATSHQIDNHIHLINPTDETVFPGINSKAIELQTWEWIYGKTPKFS
VDTSFTVLHSHVEIKVFIDVKNGRIEVCNIEAPDHWLPLEICDQLNSSLI
GSKFSPIETTVDELHSKWNILCEKIKGIM

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 2e5a Chain A Residue 3001

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2e5a Crystal structure of bovine Lipoyltransferase in complex with lipoyl-AMP
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): F126 D127 G138 T139
• Binding residue (residue number reindexed from 1): F122 D123 G134 T135
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.3.1.-
  2.3.1.200: lipoyl amidotransferase.

Gene Ontology

Molecular Function

• GO:0016746 acyltransferase activity
• GO:0017118 lipoyltransferase activity

Biological Process

• GO:0009249 protein lipoylation
• GO:0036211 protein modification process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005739 mitochondrion

External links

• PDB: RCSB:2e5a, PDBe:2e5a, PDBj:2e5a
• PDBsum: 2e5a
• PubMed: 17570395
• UniProt: O46419|LIPT_BOVIN Lipoyl amidotransferase LIPT1, mitochondrial (Gene Name=LIPT1)