Structure of PDB 2e4w Chain A Binding Site BS01

Receptor Information
>2e4w Chain A (length=518) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEI
NKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLIPLLIAGVIGGS
YSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAK
AMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGR
SNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAANRVNASFTWVA
SDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNP
WFRDFWEQKFQCSLQNKRNHRQVCDKHLAIDSSNYEQESKIMFVVNAVYA
MAHALHKMQRTLCPQTTKLCDAMKILDGKKLYKEYLLKIQFTAPFNPNKG
ADSIVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHW
SRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDC
GPGQWPTADLSGCYNLPE
Ligand information
Ligand IDC5A
InChIInChI=1S/C7H11NO4/c8-7(6(11)12)2-1-4(3-7)5(9)10/h4H,1-3,8H2,(H,9,10)(H,11,12)/t4-,7-/m0/s1
InChIKeyYFYNOWXBIBKGHB-FFWSUHOLSA-N
SMILES
SoftwareSMILES
CACTVS 3.341N[C@]1(CC[C@@H](C1)C(O)=O)C(O)=O
OpenEye OEToolkits 1.5.0C1CC(CC1C(=O)O)(C(=O)O)N
CACTVS 3.341N[C]1(CC[CH](C1)C(O)=O)C(O)=O
OpenEye OEToolkits 1.5.0C1C[C@](C[C@H]1C(=O)O)(C(=O)O)N
ACDLabs 10.04O=C(O)C1(N)CC(C(=O)O)CC1
FormulaC7 H11 N O4
Name(1S,3S)-1-aminocyclopentane-1,3-dicarboxylic acid;
1S,3S-ACPD
ChEMBLCHEMBL29726
DrugBank
ZINCZINC000001641373
PDB chain2e4w Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2e4w Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
Resolution2.4 Å
Binding residue
(original residue number in PDB)		R64 R68 S149 S151 A172 S173 T174 Y222 D301 G302 K389
Binding residue
(residue number reindexed from 1)		R35 R39 S100 S102 A123 S124 T125 Y173 D252 G253 K340
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2e4w, PDBe:2e4w, PDBj:2e4w
PDBsum2e4w
PubMed17360426
UniProtP31422|GRM3_RAT Metabotropic glutamate receptor 3 (Gene Name=Grm3)

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