Structure of PDB 2e47 Chain A Binding Site BS01

Receptor Information

>2e47 Chain A (length=155) Species: 7091 (Bombyx mori)

HGFTTPSRAIAVLSTETIRGNITFTQVQDGKVHVQGGITGLPPGEYGFHV
HEKGDLSGGCLSTGSHFNPEHKDHGHPNDVNRHVGDLGNVVFDENHYSRI
DLVDDQISLSGPHGIIGRAVVLHEKADDYGKSDHPDSRKTGNAGGRVACG
VIGIL

Ligand information

• Ligand ID: CU
• InChI: InChI=1S/Cu/q+2
• InChIKey: JPVYNHNXODAKFH-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Cu+2]
  CACTVS 3.341: [Cu++]
• Formula: Cu
• Name: COPPER (II) ION
• DrugBank: DB14552
• PDB chain: 2e47 Chain A Residue 171

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2e47 the clock protein EA4 ticks away with movement of a mobile copper ion
• Resolution: 2.11 Å
• Binding residue (original residue number in PDB): H50 H52 H67 H124
• Binding residue (residue number reindexed from 1): H49 H51 H66 H123
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): H50 H52 H67 H75 H84 D87 H124 R147
• Catalytic site (residue number reindexed from 1): H49 H51 H66 H74 H83 D86 H123 R146
• Enzyme Commision number: 1.15.1.1: superoxide dismutase.

Gene Ontology

Molecular Function

• GO:0004784 superoxide dismutase activity
• GO:0005507 copper ion binding
• GO:0016209 antioxidant activity
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006801 superoxide metabolic process
• GO:0019430 removal of superoxide radicals
• GO:0098869 cellular oxidant detoxification

External links

• PDB: RCSB:2e47, PDBe:2e47, PDBj:2e47
• PDBsum: 2e47
• UniProt: Q08J22