Structure of PDB 2dq6 Chain A Binding Site BS01

Receptor Information
>2dq6 Chain A (length=865) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLN
GEDLKLVSVHINDEPWTAWKEEEGALVISNLPERFTLKIINEISPAANTA
LEGLYQSGDALCTQCEAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFL
LSNGNRVAQGELENGRHWVQWQDPFPKPCYLFALVAGDFDVLRDTFTTRS
GREVALELYVDRGNLDRAPWAMTSLKNSMKWDEERFGLEYDLDIYMIVAV
DFFNMGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHEYFHNWTG
NRVTCRDWFQLSLKEGLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAE
DASPMAHPIRPDMVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENFQKGMQ
LYFERHDGSAATCDDFVQAMEDASNVDLSHFRRWYSQSGTPIVTVKDDYN
PETEQYTLTISQRTPATPDQAEKQPLHIPFAIELYDNEGKVIPLQKGGHP
VNSVLNVTQAEQTFVFDNVYFQPVPALLCEFSAPVKLEYKWSDQQLTFLM
RHARNDFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAVLLD
EKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVREALTRTLATELADE
LLAIYNANYQSEYRVEHEDIAKRTLRNACLRFLAFGETHLADVLVSKQFH
EANNMTDALAALSAAVAAQLPCRDALMQEYDDKWHQNGLVMDKWFILQAT
SPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAEDGSGY
LFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQEKMRAALEQLKGLE
NLSGDLYEKITKALA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2dq6 Chain A Residue 900 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2dq6 Aminopeptidase N (proteobacteria alanyl aminopeptidase) from Escherichia coli: Crystal structure and conformational change of the methionine 260 residue involved in substrate recognition
Resolution1.5 Å
Binding residue
(original residue number in PDB)		H297 H301 E320
Binding residue
(residue number reindexed from 1)		H292 H296 E315
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) E264 H297 E298 H301 E320 N373 Y381
Catalytic site (residue number reindexed from 1) E259 H292 E293 H296 E315 N368 Y376
Enzyme Commision number 3.4.11.2: membrane alanyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2dq6, PDBe:2dq6, PDBj:2dq6
PDBsum2dq6
PubMed16885166
UniProtP04825|AMPN_ECOLI Aminopeptidase N (Gene Name=pepN)

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