Structure of PDB 2dpi Chain A Binding Site BS01

Receptor Information
>2dpi Chain A (length=372) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGV
KKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGF
DENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLV
GSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPES
CQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGI
SVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELL
ASLLNRVCQDGRKPHTVRLIIRRYSSEKHYGRESRQCPIPSHVIQVMTPM
VDILMKLFRNMTLLSVCFCNLK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2dpi Hoogsteen base pair formation promotes synthesis opposite the 1,N(6)-ethenodeoxyadenosine lesion by human DNA polymerase iota.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		E127 K207 I242 G243 K245 T246 E358 S359
Binding residue
(residue number reindexed from 1)		E102 K182 I217 G218 K220 T221 E333 S334
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:2dpi, PDBe:2dpi, PDBj:2dpi
PDBsum2dpi
PubMed16819516
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

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