Structure of PDB 2ddu Chain A Binding Site BS01

Receptor Information
>2ddu Chain A (length=301) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LTLKPGYVLQFKLNIGCTSQFSSTAPVLLQYSHDAGMSWFLVKEGCFPAS
AGKGCEGNSRELSEPTVYYTGDFEEWTRITIAIPRSLASSKTRFRWIQEV
PPFGLDGVYISEPCPSYCSGHGDCISGVCFCDLGYTAAQGTCVSNTPNHS
EMFDRFEGKLSPLWYKITGGQVGTGCGTLNDGRSLYFNGLGKREARTVPL
DTRNIRLVQFYIQIGSKTSGITCIKPRARNEGLVVQYSNDNGILWHLLRE
LDFMSFLEPQIISIDLPREAKTPATAFRWWQPQHGKHSAQWALDDVLISR
L
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain2ddu Chain A Residue 1 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2ddu Structure of a signaling-competent reelin fragment revealed by X-ray crystallography and electron tomography
Resolution2.05 Å
Binding residue
(original residue number in PDB)		R1454 E1456 D1480 R1482 D1593
Binding residue
(residue number reindexed from 1)		R155 E157 D181 R183 D294
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.21.-
Gene Ontology
Molecular Function
GO:0070325 lipoprotein particle receptor binding
Biological Process
GO:0001764 neuron migration
GO:0007417 central nervous system development

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Molecular Function
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Biological Process
External links
PDB RCSB:2ddu, PDBe:2ddu, PDBj:2ddu
PDBsum2ddu
PubMed16858396
UniProtQ60841|RELN_MOUSE Reelin (Gene Name=Reln)

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