Structure of PDB 2dcu Chain A Binding Site BS01

Receptor Information
>2dcu Chain A (length=407) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KTRQAEVNIGMVGHVDHGKTTLTKALTGVWTDTHSEELRRGITIKIGFAD
AEIRRCSNCGRYSTSPICPYCGHETEFIRRVSFIDSPGHEALMTTMLAGA
SLMDGAILVIAANEPCPRPQTREHLMALQIIGQKNIIIAQNKIELVDKEK
ALENYRQIKEFIKGTVAENAPIIPISALHGANIDVLVKAIEEFIPTPKRD
SNKPPKMLVLRSFDVNKPGTPPEKLVGGVLDGSIVQGKLKVGDEIEIRPG
VPYEEHGRIKYEPITTEIVSLQAGGQFVEEAYPGGLVGIGTKLDPYLTKG
DLMAGNVVGKPGKLPPVWTDLRLEVHLLERVVGTEQELNVEPIKRKEVLL
LNVGTARTMGLVTALGKDEIELKLQIPVCAEPGERVAISRQIGSRWRLIG
YGIIKEL
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain2dcu Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2dcu Structure of archaeal translational initiation factor 2 betagamma-GDP reveals significant conformational change of the beta-subunit and switch 1 region.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		T25 P92
Binding residue
(residue number reindexed from 1)		T20 P87
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D21 K24 T25 T48 H94
Catalytic site (residue number reindexed from 1) D16 K19 T20 T43 H89
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003743 translation initiation factor activity
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation
Cellular Component
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2dcu, PDBe:2dcu, PDBj:2dcu
PDBsum2dcu
PubMed16924118
UniProtQ8U082|IF2G_PYRFU Translation initiation factor 2 subunit gamma (Gene Name=eif2g)

[Back to BioLiP]