Structure of PDB 2d7s Chain A Binding Site BS01

Receptor Information

>2d7s Chain A (length=474) Species: 244367 (Foot-and-mouth disease virus C-S8c1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GLIVDTRDVEERVHVMRKTKLAPTVAHGVFNPEFGPAALSNKDPRLNEGV
VLDEVIFSKHKGDTKMSAEDKALFRRCAADYASRLHSVLGTANAPLSIYE
AIKGVDGLDAMEPDTAPGLPWALQGKRRGALIDFENGTVGPEVEAALKLM
EKREYKFACQTFLKDEIRPMEKVRAGKTRIVDVLPVEHILYTRMMIGRFC
AQMHSNNGPQIGSAVGCNPDVDWQRFGTHFAQYRNVWDVDYSAFDANHCS
DAMNIMFEEVFRTEFGFHPNAEWILKTLVNTEHAYENKRITVEGGMPSGC
SATSIINTILNNIYVLYALRRHYEGVELDTYTMISYGDDIVVASDYDLDF
EALKPHFKSLGQTITPADKSDKGFVLGHSITDVTFLKRHFHMDYGTGFYK
PVMASKTLEAILSFARRGTIQEKLISVAGLAVHSGPDEYRRLFEPFQGLF
EIPSYRSLYLRWVNAVCGDAAALE

Ligand information

>2d7s Chain B (length=15) Species: 12116 (Foot and mouth disease virus C) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

GPYAGPLERQRPLKV

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2d7s The structure of a protein primer-polymerase complex in the initiation of genome replication
Resolution	3.0 Å
Binding residue (original residue number in PDB)	F34 E166 I167 R168 R179 G216 C217 Y336 K387 R388 T407 I411
Binding residue (residue number reindexed from 1)	F34 E166 I167 R168 R179 G216 C217 Y336 K387 R388 T407 I411

Enzymatic activity

Enzyme Commision number

3.4.22.46: L-peptidase.
3.6.1.15: nucleoside-triphosphate phosphatase.

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003968	RNA-dependent RNA polymerase activity

	Biological Process
GO:0006351	DNA-templated transcription
GO:0039694	viral RNA genome replication

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Molecular Function

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Biological Process

External links

PDB	RCSB:2d7s, PDBe:2d7s, PDBj:2d7s
PDBsum	2d7s
PubMed	16456546
UniProt	Q9QCE4

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