Structure of PDB 2d74 Chain A Binding Site BS01

Receptor Information
>2d74 Chain A (length=403) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KTRQAEVNIGMVGHVDHGKTTLTKALTGVWTDTLRRGITIKIGFADAEIR
RCSNCGRYSTSPICPYCGHETEFIRRVSFIDSPGHEALMTTMLAGASLMD
GAILVIAANEPCPRPQTREHLMALQIIGQKNIIIAQNKIELVDKEKALEN
YRQIKEFIKGTVAENAPIIPISALHGANIDVLVKAIEEFIPTPKRDSNKP
PKMLVLRSFDVNKPGTPPEKLVGGVLDGSIVQGKLKVGDEIEIRPGVPYE
EHGRIKYEPITTEIVSLQAGGQFVEEAYPGGLVGIGTKLDPYLTKGDLMA
GNVVGKPGKLPPVWTDLRLEVHLLERVVGTEQELNVEPIKRKEVLLLNVG
TARTMGLVTALGKDEIELKLQIPVCAEPGERVAISRQIGSRWRLIGYGII
KEL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2d74 Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2d74 Structure of archaeal translational initiation factor 2 betagamma-GDP reveals significant conformational change of the beta-subunit and switch 1 region.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		C61 C64 C73 C76
Binding residue
(residue number reindexed from 1)		C52 C55 C64 C67
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D21 K24 T25 T48 H94
Catalytic site (residue number reindexed from 1) D16 K19 T20 T39 H85
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003743 translation initiation factor activity
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2d74, PDBe:2d74, PDBj:2d74
PDBsum2d74
PubMed16924118
UniProtQ8U082|IF2G_PYRFU Translation initiation factor 2 subunit gamma (Gene Name=eif2g)

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