Structure of PDB 2d3y Chain A Binding Site BS01

Receptor Information
>2d3y Chain A (length=219) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDREAFVQTLTACRLCPRLVAWREEVVGRKRAFRGEPYWARPVPGFGDPE
ARILLFGLAPGAHGSNRTGRPFTGDASGAFLYPLLHEAGLSSKPESLPGD
DLRLYGVYLTAAVRCAPPKNKPTPEELRACARWTEVELGLLPEVRVYVAL
GRIALEALLAHFGLRKSAHPFRHGAHYPLPGGRHLLASYHVSRQNTQTGR
LTREMFLEVLMEAKRLAGL
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain2d3y Chain A Residue 220 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2d3y Crystal structure of family 5 uracil-DNA glycosylase bound to DNA.
Resolution1.55 Å
Binding residue
(original residue number in PDB)		C13 L15 C16 P42 C115 C130 W133
Binding residue
(residue number reindexed from 1)		C13 L15 C16 P42 C115 C130 W133
Annotation score4
Enzymatic activity
Enzyme Commision number 3.2.2.-
Gene Ontology
Molecular Function
GO:0004844 uracil DNA N-glycosylase activity
GO:0016787 hydrolase activity
GO:0033958 DNA-deoxyinosine glycosylase activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0097506 deaminated base DNA N-glycosylase activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:2d3y, PDBe:2d3y, PDBj:2d3y
PDBsum2d3y
PubMed17870091
UniProtQ5SJ65|UDGB_THET8 Type-5 uracil-DNA glycosylase (Gene Name=udgb)

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