Structure of PDB 2d1k Chain A Binding Site BS01

Receptor Information
>2d1k Chain A (length=371) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSY
VGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPT
LLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVL
DSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTT
AEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNE
RFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGT
TMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQ
QMWITKQEYDEAGPSIVHRKC
Ligand information
>2d1k Chain C (length=29) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
TPQGEDMLNAIRRGVKLKKTTTNDRSAPR
Receptor-Ligand Complex Structure
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PDB2d1k Structural basis for the actin-binding function of missing-in-metastasis
Resolution2.5 Å
Binding residue
(original residue number in PDB)		L16 G23 D24 D25 A26 P27 V30 D56 E93 Y143 G146 R147 T148 E167 Y169 A204 E207 R210 Y337 I345 L349 Q354 M355
Binding residue
(residue number reindexed from 1)		L13 G20 D21 D22 A23 P24 V27 D53 E90 Y140 G143 R144 T145 E164 Y166 A201 E204 R207 Y334 I342 L346 Q351 M352
Enzymatic activity
Enzyme Commision number 3.6.4.-
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003785 actin monomer binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005523 tropomyosin binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0019904 protein domain specific binding
GO:0031013 troponin I binding
GO:0031432 titin binding
GO:0032036 myosin heavy chain binding
GO:0042802 identical protein binding
GO:0048306 calcium-dependent protein binding
GO:0140660 cytoskeletal motor activator activity
Biological Process
GO:0010628 positive regulation of gene expression
GO:0030041 actin filament polymerization
GO:0030240 skeletal muscle thin filament assembly
GO:0048741 skeletal muscle fiber development
GO:0051017 actin filament bundle assembly
GO:0090131 mesenchyme migration
Cellular Component
GO:0001725 stress fiber
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005865 striated muscle thin filament
GO:0005884 actin filament
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0031941 filamentous actin
GO:0032432 actin filament bundle
GO:0044297 cell body
GO:0098723 skeletal muscle myofibril

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Biological Process
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Cellular Component
External links
PDB RCSB:2d1k, PDBe:2d1k, PDBj:2d1k
PDBsum2d1k
PubMed17292833
UniProtP68135|ACTS_RABIT Actin, alpha skeletal muscle (Gene Name=ACTA1)

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