Structure of PDB 2d0c Chain A Binding Site BS01

Receptor Information
>2d0c Chain A (length=308) Species: 1422 (Geobacillus stearothermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SNYVIQADQQLLDALRAHYEGALSDRLPAGALFAVKRPDVVITAYRSGKV
LFQGKAAEQEAAKWISGASASNETADHQPSALAAHQLGSLSAIGSDEVGT
GDYFGPIVVAAAYVDRPHIAKIAALGVKDSKQLNDEAIKRIAPAIMETVP
HAVTVLDNPQYNRWQRSGMPQTKMKALLHNRTLVKLVDAIAPAEPEAIII
DEFLKRDSYFRYLSDEDRIIRERVHCLPKAESVHVSVAAASIIARYVFLE
EMEQLSRAVGLLLPKGAGAIVDEAAARIIRARGEEMLETCAKLHFANTKK
ALAIAKRR
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain2d0c Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2d0c Crystal structure and structure-based mutational analyses of RNase HIII from Bacillus stearothermophilus: a new type 2 RNase H with TBP-like substrate-binding domain at the N terminus
Resolution2.6 Å
Binding residue
(original residue number in PDB)		D97 E98 D202
Binding residue
(residue number reindexed from 1)		D96 E97 D201
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.26.4: ribonuclease H.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006298 mismatch repair
GO:0006401 RNA catabolic process
GO:0016070 RNA metabolic process
GO:0043137 DNA replication, removal of RNA primer
Cellular Component
GO:0005737 cytoplasm
GO:0032299 ribonuclease H2 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2d0c, PDBe:2d0c, PDBj:2d0c
PDBsum2d0c
PubMed16343535
UniProtQ6L6Q4

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