Structure of PDB 2cvy Chain A Binding Site BS01

Receptor Information
>2cvy Chain A (length=640) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TKQFSKVVEDLYRYVNAATGKPAPMISDDVYNIVMENKDKLNSAIVYDRD
FQYSYFGFKTLERSYLLRINGQVAERPQHLIMRVALGIHGRDIEAALETY
NLMSLKYFTHASPTLFNAGTPKPQMSSCFLVAMKEDSIEGIYDTLKECAL
ISKTAGGIGLHIHNIRSTGSYIAGTNGTSNGLIPMIRVFNNTARYVAFAL
YLEPWHADIFDFIDIRKNHGKEEIRARDLFPALWIPDLFMKRVEENGTWT
LFSPTSAPGLSDCYGDEFEALYTRYEKEGRGKTIKAQKLWYSILEAQTET
GTPFVVYKDACNRKSNQKNLGVIKSSNLCCEIVEYSAPDETAVCNLASVA
LPAFIETSEDGKTSTYNFKKLHEIAKVVTRNLNRVIDRNYYPVEEARKSN
MRHRPIALGVQGLADTFMLLRLPFDSEEARLLNIQIFETIYHASMEASCE
LAQKDGPYETFQGSPASQGILQFDMWDQKPYGMWDWDTLRKDIMKHGVRN
SLTMAPMPTASTSQILGYNECFEPVTSNMYSFQVVNPYLLRDLVDLGIWD
EGMKQYLITQNGSIQGLPNVPQELKDLYKTVWEISQKTIINMAADRSVYI
DQSHSLNLFLRAPTMGKLTSMHFYGWKKGLKTGMYYLRTQ
Ligand information
>2cvy Chain B (length=7) Species: 559292 (Saccharomyces cerevisiae S288C) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
FTFNEDF
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2cvy Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Resolution2.4 Å
Binding residue
(original residue number in PDB)		E343 Q386 Q692 K693 G722 T725 S726 M727 F729 Y730
Binding residue
(residue number reindexed from 1)		E244 Q287 Q586 K587 G616 T619 S620 M621 F623 Y624
Enzymatic activity
Catalytic site (original residue number in PDB) C218 N426 C428 E430 C443 Y741 Y742
Catalytic site (residue number reindexed from 1) C128 N327 C329 E331 C344 Y635 Y636
Enzyme Commision number 1.17.4.1: ribonucleoside-diphosphate reductase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
Biological Process
GO:0009263 deoxyribonucleotide biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005971 ribonucleoside-diphosphate reductase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2cvy, PDBe:2cvy, PDBj:2cvy
PDBsum2cvy
PubMed16537479
UniProtP21524|RIR1_YEAST Ribonucleoside-diphosphate reductase large chain 1 (Gene Name=RNR1)

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