Structure of PDB 2csx Chain A Binding Site BS01

Receptor Information
>2csx Chain A (length=464) Species: 63363 (Aquifex aeolicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTLMKKFYVTTPIYYVNDVPHLGHAYTTIAADTIARYYRLRDYDVFFLTG
TDEHGLKIQKKAEELGISPKELVDRNAERFKKLWEFLKIEYTKFIRTTDP
YHVKFVQKVFEECYKRGDIYLGEYKEPSYFFRLSKYQDKLLELYEKNPEF
IQPDYRRNEIISFVKQGLKDLSVTRPRSRVKWGIPVPFDPEHTIYVWFDA
LFNYISALEDKVEIYWPADLHLVGKDILRFHTVYWPAFLMSLGYELPKKV
FAHGWWTVEGKKMSKTLGNVVDPYEVVQEYGLDEVRYFLLREVPFGQDGD
FSKKAILNRINGELANEIGNLYSRVVNMAHKFLGGEVSGARDEEYAKIAQ
ESIKNYENYMEKVNFYKAIEEILKFTSYLNKYVDEKQPWALNKERKKEEL
QKVLYALVDGLFVLTHLLYPITPNKMKEALQMLGEKEFLKELKPYSKNTY
KLGERKILFPKREG
Ligand information
>2csx Chain C (length=75) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggcggcguagcucagcuggucagagcggggaucucauaagucccaggucg
gagguucgaguccucccgccgccac
<<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<
<<<<.......>>>>>>>>>>>>..
Receptor-Ligand Complex Structure
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PDB2csx Structural basis for anticodon recognition by methionyl-tRNA synthetase.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		N349 G352 N353 S356 R357 N360 M361 K414 D417 W422 I490 F492 K494
Binding residue
(residue number reindexed from 1)		N316 G319 N320 S323 R324 N327 M328 K381 D384 W389 I457 F459 K461
Enzymatic activity
Catalytic site (original residue number in PDB) I13 W230 I260 K295 K298
Catalytic site (residue number reindexed from 1) I13 W197 I227 K262 K265
Enzyme Commision number 6.1.1.10: methionine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004825 methionine-tRNA ligase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006431 methionyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Biological Process
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Cellular Component
External links
PDB RCSB:2csx, PDBe:2csx, PDBj:2csx
PDBsum2csx
PubMed16155581
UniProtO67298|SYM_AQUAE Methionine--tRNA ligase (Gene Name=metG)

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