Structure of PDB 2cjb Chain A Binding Site BS01

Receptor Information
>2cjb Chain A (length=474) Species: 269797 (Methanosarcina barkeri str. Fusaro) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHMKLQFNLKAYFKTKDAIAALFEEANSTLLTRGAPEGQGATEWDRIELT
LQSGRYVRVHDAIFRLRKQLAEIEVESFIIKVPADHELRMLKVPYIKSME
NIEGGIQLELEVGEAEMKNRVPDRILTLLEEKIEAAQEHWNLLWQREPME
HPFKEDPTQAMMKEGWLKRGSSRGQWIHGPQSARIFRTFEKIVLEELLEP
LGYREMIFPKLVTWEVWMKSGHAKGVYPEIYYVCPPQTRDPDYWEEVADY
YKVTHEVPTKLIKEKIAEPIGGMCYAQCPPFWMYVAGETLPNEEIPVKVF
DRSGTSHRYESGGIHGIERVDEFHRIEIVWIGTKEEVLKCAEELHDRYMH
IFNDILDIEWRKARVTPWFMAQEGLLGLAEENTVGTTDYEACLPYRGPDG
EWLEFQNVSINGDKYPKGFNVKLQSGDELWSGCSGVGLERWAAVFLAQKG
LDPANWPEEFRNRVGEMPKGIRFL
Ligand information
Ligand IDSER
InChIInChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKeyMTCFGRXMJLQNBG-REOHCLBHSA-N
SMILES
SoftwareSMILES
CACTVS 3.341N[CH](CO)C(O)=O
OpenEye OEToolkits 1.5.0C(C(C(=O)O)N)O
CACTVS 3.341N[C@@H](CO)C(O)=O
ACDLabs 10.04O=C(O)C(N)CO
OpenEye OEToolkits 1.5.0C([C@@H](C(=O)O)N)O
FormulaC3 H7 N O3
NameSERINE
ChEMBLCHEMBL11298
DrugBankDB00133
ZINCZINC000000895034
PDB chain2cjb Chain A Residue 1505 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2cjb Structure of the Unusual Seryl-tRNA Synthetase Reveals a Distinct Zinc-Dependent Mode of Substrate Recognition
Resolution2.7 Å
Binding residue
(original residue number in PDB)		A304 R353 E355 W396 Q400
Binding residue
(residue number reindexed from 1)		A276 R325 E327 W368 Q372
Annotation score5
Enzymatic activity
Catalytic site (original residue number in PDB) C306 R336 E338 R347 E355 D416 E432 N435 C461 R468
Catalytic site (residue number reindexed from 1) C278 R308 E310 R319 E327 D388 E404 N407 C433 R440
Enzyme Commision number 6.1.1.11: serine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004828 serine-tRNA ligase activity
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006434 seryl-tRNA aminoacylation
GO:0016260 selenocysteine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2cjb, PDBe:2cjb, PDBj:2cjb
PDBsum2cjb
PubMed16675947
UniProtQ46AN5|SYS2_METBF Type-2 serine--tRNA ligase (Gene Name=serS2)

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