Structure of PDB 2cim Chain A Binding Site BS01

Receptor Information
>2cim Chain A (length=487) Species: 269797 (Methanosarcina barkeri str. Fusaro) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKLQFNLKAYFKTSADPTPAKDAIAALFEEANSTLLTRGAPEGQGAKVTE
WKLGEDRIELTLQSGRYVRVHDAIFRLRKQLAEALGKKYKIGIRGIEVES
FIIKVPADHELRMLKVPYIKSMENIEGGIQLELEVGEAEMKNRVPDRILT
LLEEKIEAAQYGAKAEHWNLLWQREPMEHPFKEDPTQAMMKEGWLKRGSS
RGQWIHGPQSARIFRTFEKIVLEELLEPLGYREMIFPKLVTWEVWMKSGH
AKGVYPEIYYVCPPQTRDPDYWEEVADYYKVTHEVPTKLIKEKIAEPIGG
MCYAQCPPFWMYVAGETLPNEEIPVKVFDRSGTSHRYESGGIHGIERVDE
FHRIEIVWIGTKEEVLKCAEELHDRYMHIFNDILDIEWRKARVTNTVGTT
DYEACLPYRGPDGEWLEFQNVSINGDKYPKGFNVKLQSGDELWSGCSGVG
LERWAAVFLAQKGLDPANWPEEFRNRVGEMPKGIRFL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2cim Chain A Residue 1503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2cim Structure of the Unusual Seryl-tRNA Synthetase Reveals a Distinct Zinc-Dependent Mode of Substrate Recognition
Resolution2.51 Å
Binding residue
(original residue number in PDB)		C306 E355 C461
Binding residue
(residue number reindexed from 1)		C306 E355 C446
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) C306 R336 E338 R347 E355 D416 E432 N435 C461 R468
Catalytic site (residue number reindexed from 1) C306 R336 E338 R347 E355 D401 E417 N420 C446 R453
Enzyme Commision number 6.1.1.11: serine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004828 serine-tRNA ligase activity
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006434 seryl-tRNA aminoacylation
GO:0016260 selenocysteine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2cim, PDBe:2cim, PDBj:2cim
PDBsum2cim
PubMed16675947
UniProtQ46AN5|SYS2_METBF Type-2 serine--tRNA ligase (Gene Name=serS2)

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