Structure of PDB 2cbl Chain A Binding Site BS01

Receptor Information
>2cbl Chain A (length=305) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLR
TILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQ
PRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGE
KTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTR
LFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLS
CTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQN
PDLTG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2cbl Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		S80 P81 Y274 R294 S296 C297 T298 Y307 Q316 T317 I318 P319 F336 Y337
Binding residue
(residue number reindexed from 1)		S34 P35 Y228 R248 S250 C251 T252 Y261 Q270 T271 I272 P273 F290 Y291
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0001784 phosphotyrosine residue binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005509 calcium ion binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0023051 regulation of signaling

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Molecular Function
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Biological Process
External links
PDB RCSB:2cbl, PDBe:2cbl, PDBj:2cbl
PDBsum2cbl
PubMed10078535
UniProtP22681|CBL_HUMAN E3 ubiquitin-protein ligase CBL (Gene Name=CBL)

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