Structure of PDB 2c77 Chain A Binding Site BS01

Receptor Information

>2c77 Chain A (length=404) Species: 300852 (Thermus thermophilus HB8)

KGEFIRTKPHVNVGTIGHVDHGKTTLTAALTYVTAAENPNVEVKDYGDID
KAPEERARGITINTAHVEYETAKRHYSHVDCPGHADYIKNMITGAAQMDG
AILVVSAADGPMPQTREHILLARQVGVPYIVVFMNKVDMVDDPELLDLVE
MEVRDLLNQYEFPGDEVPVIRGSALLALEQMHRNPKTRRGENEWVDKIWE
LLDAIDEYIPTPVRDVDKPFLMPVEDVFTITGRGTVATGRIERGKVKVGD
EVEIVGLAPETRKTVVTGVEMHRKTLQEGIAGDNVGVLLRGVSREEVERG
QVLAKPGSITPHTKFEASVYVLKKEEGGRHTGFFSGYRPQFYFRTTDVTG
VVQLPPGVEMVMPGDNVTFTVELIKPVALEEGLRFAIREGGRTVGAGVVT
KILE

Ligand information

>2c77 Chain B (length=14) Species: 35762 (Planobispora rosea)

SCNCVCGFCCSCSP

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2c77 Structural basis of the action of pulvomycin and GE2270 A on elongation factor Tu.
• Resolution: 1.6 Å
• Binding residue (original residue number in PDB): H67 V68 S78 Q98 E226 D227 R234 T239 G269 E271 H273 R274 N285 V286 G287 L289
• Binding residue (residue number reindexed from 1): H66 V67 S77 Q97 E225 D226 R233 T238 G268 E270 H272 R273 N284 V285 G286 L288

Enzymatic activity

• Catalytic site (original residue number in PDB): D21 K24 T25 T62 H85
• Catalytic site (residue number reindexed from 1): D20 K23 T24 T61 H84
• Enzyme Commision number: 3.1.5.1: dGTPase.

Gene Ontology

Molecular Function

• GO:0003746 translation elongation factor activity
• GO:0003924 GTPase activity
• GO:0005525 GTP binding

Biological Process

• GO:0006412 translation
• GO:0006414 translational elongation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:2c77, PDBe:2c77, PDBj:2c77
• PDBsum: 2c77
• PubMed: 16734421
• UniProt: P60339|EFTU2_THET8 Elongation factor Tu-B (Gene Name=tufB)