Structure of PDB 2bz0 Chain A Binding Site BS01

Receptor Information

>2bz0 Chain A (length=168) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARV
HSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLN
KIRAYALQDQGYDTVEGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKV
EILTEAGINIVERVPLIV

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

2bz0 Chain A Residue 1174 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2bz0 GTP Cyclohydrolase II Structure and Mechanism.
Resolution	2.6 Å
Binding residue (original residue number in PDB)	C54 C65 C67
Binding residue (residue number reindexed from 1)	C54 C65 C67
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.5.4.25: GTP cyclohydrolase II.

Gene Ontology

	Molecular Function
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0003935	GTP cyclohydrolase II activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

	Biological Process
GO:0009231	riboflavin biosynthetic process

	Cellular Component
GO:0005829	cytosol

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Cellular Component

External links

PDB	RCSB:2bz0, PDBe:2bz0, PDBj:2bz0
PDBsum	2bz0
PubMed	16115872
UniProt	P0A7I7\|RIBA_ECOLI GTP cyclohydrolase-2 (Gene Name=ribA)

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