Structure of PDB 2bkw Chain A Binding Site BS01

Receptor Information
>2bkw Chain A (length=381) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KSVDTLLIPGPIILSGAVQKALDVPSLGHTSPEFVSIFQRVLKNTRAVFK
SAAASKSQPFVLAGSGTLGWDIFASNFILSKAPNKNVLVVSTGTFSDRFA
DCLRSYGAQVDVVRPLKIGESVPLELITEKLSQNSYGAVTVTHVDTSTAV
LSDLKAISQAIKQTSPETFFVVDAVCSIGCEEFEFDEWGVDFALTASQKA
IGAPAGLSISLCSSRFMDYALNDSKNGHVHGYFSSLRRWTPIMENYEAGK
GAYFATPPVQLINSLDVALKEILEEGLHKRWDLHREMSDWFKDSLVNGLQ
LTSVSRYPSNMSAHGLTAVYVADPPDVIAFLKSHGVVIAGGIHKDIGPKY
IRIGHMGVTACNKNLPYMKNCFDLIKLALQR
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain2bkw Chain A Residue 1201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2bkw Crystal Structure and Confirmation of the Alanine:Glyoxylate Aminotransferase Activity of the Yfl030W Yeast Protein
Resolution2.57 Å
Binding residue
(original residue number in PDB)		S67 G68 T69 F97 T148 D175 V177 K201 R383
Binding residue
(residue number reindexed from 1)		S65 G66 T67 F95 T146 D173 V175 K199 R381
Annotation score1
Enzymatic activity
Enzyme Commision number 2.6.1.44: alanine--glyoxylate transaminase.
Gene Ontology
Molecular Function
GO:0004760 L-serine-pyruvate transaminase activity
GO:0008453 alanine-glyoxylate transaminase activity
GO:0008483 transaminase activity
Biological Process
GO:0006545 glycine biosynthetic process
GO:0019265 glycine biosynthetic process, by transamination of glyoxylate
Cellular Component
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2bkw, PDBe:2bkw, PDBj:2bkw
PDBsum2bkw
PubMed16226833
UniProtP43567|AGX1_YEAST Alanine--glyoxylate aminotransferase 1 (Gene Name=AGX1)

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