Structure of PDB 2bba Chain A Binding Site BS01
Receptor Information
>2bba Chain A (length=185) Species:
9606
(Homo sapiens) [
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HHHHHEETLLNTKLETADLKWVTFPQVDGQWEELSGLDEEQHSVRTYEVC
DVQRAPGQAHWLRTGWVPRRGAVHVYATLRFTMLECLSLPRAGRSCKETF
TVFYYESDADTATALTPAWMENPYIKVDTVAAEHLTRKRPGAEATGKVNV
KTLRLGPLSKAGFYLAFQDQGACMALLSLHLFYKK
Ligand information
>2bba Chain P (length=14) [
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NYLFSPNGPIARAW
Receptor-Ligand Complex Structure
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PDB
2bba
Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity.
Resolution
1.65 Å
Binding residue
(original residue number in PDB)
E43 L45 G47 E59 C61 T93 L95 P101 K149 A155 G157 M185
Binding residue
(residue number reindexed from 1)
E32 L34 G36 E48 C50 T82 L84 P90 K138 A144 G146 M174
Enzymatic activity
Enzyme Commision number
2.7.10.1
: receptor protein-tyrosine kinase.
External links
PDB
RCSB:2bba
,
PDBe:2bba
,
PDBj:2bba
PDBsum
2bba
PubMed
16472751
UniProt
P54760
|EPHB4_HUMAN Ephrin type-B receptor 4 (Gene Name=EPHB4)
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