Structure of PDB 2b9s Chain A Binding Site BS01

Receptor Information
>2b9s Chain A (length=426) Species: 5661 (Leishmania donovani) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DLNWWEQENLRIAMKGERRWETLAHNGVLFPPEYEPHGIPIFYDGREFKM
TPEEEEVATMFAVMKEHDYYRMEVFRRNFFESWREILDKRQHPIRRLELC
DFEPIYQWHLVQREKKLSRTKEEKKAIKEKQDAEAEPYRYCVWDGRREQV
ANFRVEPPGLFRGRGKHPLMGKLKVRVQPEDITINIGETAEVPVPPAGHK
WAAVQHDHTVTWLAMWRDSVAGNMKYVMLAPSSSVKGQSDMVKFEKARKL
KDKVDDIRASYMEDFKSNDLHVAQRAVAMYFIDRLALRVGNEKGEDEADT
VGCCSLRVEHIQLMPDNIVRFDFLGKDSIRYQNDVAVLPEVYALLQRFTR
RKSPGMDIFDQLNPTQLNDHLKSFMDGLSAKVFRTYNASITLDRWFKEKP
WSTADKLAYFNKANTEVAILCNHQKS
Ligand information
Receptor-Ligand Complex Structure
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PDB2b9s The Structure of the Transition State of the Heterodimeric Topoisomerase I of Leishmania donovani as a Vanadate Complex with Nicked DNA.
Resolution2.27 Å
Binding residue
(original residue number in PDB)		K41 V236 T237 W238 M250 Y252 K269 K352 K407
Binding residue
(residue number reindexed from 1)		K15 V210 T211 W212 M224 Y226 K243 K326 K381
Enzymatic activity
Enzyme Commision number 5.6.2.1: DNA topoisomerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
Biological Process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2b9s, PDBe:2b9s, PDBj:2b9s
PDBsum2b9s
PubMed16487540
UniProtQ9GPZ9

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