Structure of PDB 2b7p Chain A Binding Site BS01

Receptor Information
>2b7p Chain A (length=273) Species: 210 (Helicobacter pylori) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEIRTFLERALKEDLGHGDLFERVLEKDFKATAFVRAKQEGVFSGEKYAL
ELLEMTGIECVQTIKDKERFKPKDALMEIRGDFSMLLKVERTLLNLLQHS
SGIATLTSRFVEALNSHKVRLLDTRKTRPLLRIFEKYSVLNGGASNHRLG
LDDALMLKDTHLRHVKDLKSFLTHARKNLPFTAKIEIECESFEEAKNAMN
AGADIVMCDNLSVLETKEIAAYRDAHYPFVLLEASGNISLESINAYAKSG
VDAISVGALIHQATFIDMHMKMA
Ligand information
Ligand IDPHT
InChIInChI=1S/C8H6O4/c9-7(10)5-3-1-2-4-6(5)8(11)12/h1-4H,(H,9,10)(H,11,12)
InChIKeyXNGIFLGASWRNHJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341OC(=O)c1ccccc1C(O)=O
ACDLabs 10.04O=C(O)c1ccccc1C(=O)O
OpenEye OEToolkits 1.5.0c1ccc(c(c1)C(=O)O)C(=O)O
FormulaC8 H6 O4
NamePHTHALIC ACID
ChEMBLCHEMBL1045
DrugBankDB02746
ZINCZINC000000090750
PDB chain2b7p Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2b7p Crystal structure of quinolinic acid phosphoribosyltransferase from Helicobacter pylori
Resolution2.51 Å
Binding residue
(original residue number in PDB)		T124 R125 H147 R148 M156 M207
Binding residue
(residue number reindexed from 1)		T124 R125 H147 R148 M156 M207
Annotation score2
Enzymatic activity
Catalytic site (original residue number in PDB) R91 K126 K158 E188 D209
Catalytic site (residue number reindexed from 1) R91 K126 K158 E188 D209
Enzyme Commision number 2.4.2.19: nicotinate-nucleotide diphosphorylase (carboxylating).
Gene Ontology
Molecular Function
GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
Biological Process
GO:0009435 NAD biosynthetic process
GO:0019363 pyridine nucleotide biosynthetic process
GO:0034213 quinolinate catabolic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:2b7p, PDBe:2b7p, PDBj:2b7p
PDBsum2b7p
PubMed16419067
UniProtO25909|NADC_HELPY Probable nicotinate-nucleotide pyrophosphorylase [carboxylating] (Gene Name=nadC)

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