Structure of PDB 2b7f Chain A Binding Site BS01

Receptor Information
>2b7f Chain A (length=116) Species: 11908 (Human T-cell leukemia virus type I) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PVIPLDPARRPVIKAQVDTQTSHPKTIEALLDTGADMTVIPIALFSSNTP
LKNTSVLGAGGQTQDHFKLTSLPVLIRLPFRTTPIVLTSCLVDTKNNWAI
IGRDALQQCQGVLYLP
Ligand information
Receptor-Ligand Complex Structure
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PDB2b7f Crystal structure of human T cell leukemia virus protease, a novel target for anticancer drug design
Resolution2.6 Å
Binding residue
(original residue number in PDB)		R10 D32 G34 A35 D36 M37 S55 V56 L57 Q62 W98
Binding residue
(residue number reindexed from 1)		R10 D32 G34 A35 D36 M37 S55 V56 L57 Q62 W98
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2b7f, PDBe:2b7f, PDBj:2b7f
PDBsum2b7f
PubMed16352712
UniProtP03362|POL_HTL1A Gag-Pro-Pol polyprotein (Gene Name=gag-pro-pol)

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