Structure of PDB 2b18 Chain A Binding Site BS01

Receptor Information

>2b18 Chain A (length=155) Species: 1423 (Bacillus subtilis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MALLQKTRIINSMLQAAAGKPVNFKEMAETLRDVIDSNIFVVSRRGKLLG
YSINQQIENDRMKKMLEDRQFPEEYTKNLFNVPETSSNLDINSEYTAFPV
ENRDLFQAGLTTIVPIIGGGERLGTLILSRLQDQFNDDDLILAEYGATVV
GMEIL

Ligand information

Ligand ID

ILE

InChI

InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1

InChIKey

AGPKZVBTJJNPAG-WHFBIAKZSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 1.5.0	CC[C@H](C)[C@@H](C(=O)O)N
OpenEye OEToolkits 1.5.0	CCC(C)C(C(=O)O)N
CACTVS 3.341	CC[CH](C)[CH](N)C(O)=O
ACDLabs 10.04	O=C(O)C(N)C(C)CC
CACTVS 3.341	CC[C@H](C)[C@H](N)C(O)=O

Formula

C6 H13 N O2

Name

ISOLEUCINE

PDB chain

2b18 Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	2b18 The Structure of CodY, a GTP- and Isoleucine-responsive Regulator of Stationary Phase and Virulence in Gram-positive Bacteria.
Resolution	1.8 Å
Binding residue (original residue number in PDB)	R61 F71 T96 A97 F98 V100
Binding residue (residue number reindexed from 1)	R61 F71 T96 A97 F98 V100
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003700	DNA-binding transcription factor activity
GO:0005525	GTP binding

	Biological Process
GO:0045892	negative regulation of DNA-templated transcription

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:2b18, PDBe:2b18, PDBj:2b18
PDBsum	2b18
PubMed	16488888
UniProt	P39779\|CODY_BACSU Global transcriptional regulator CodY (Gene Name=codY)

[Back to BioLiP]