Structure of PDB 2ax3 Chain A Binding Site BS01

Receptor Information

>2ax3 Chain A (length=491) Species: 243274 (Thermotoga maritima MSB8)

HHMKEIDELTIKEYGVDSRILMERAGISVVLAMEEELGNLSDYRFLVLCG
GGNNGGDGFVVARNLLGVVKDVLVVFLGKKKTPDCEYNYGLYKKFGGKVV
EQFEPSILNEFDVVVDAIFGTGLRGEITGEYAEIINLVNKSGKVVVSVDV
PSGIDSNTGKVLRTAVKADLTVTFGVPKIGHILFPGRDLTGKLKVANIGH
PVHLINSINRYVITREMVRSLLPERPRDSHKGTYGKVLIIAGSRLYSGAP
VLSGMGSLKVGTGLVKLAVPFPQNLIATSRFPELISVPIDTEKGFFSLQN
LQECLELSKDVDVVAIGPGLGNNEHVREFVNEFLKTLEKPAVIDADAINV
LDTSVLKERKSPAVLTPHPGEMARLVKKTVGDVKYNYELAEEFAKENDCV
LVLKSATTIVTDGEKTLFNITGNTGLSKGGSGDVLTGMIAGFIAQGLSPL
EASTVSVYLHGFAAELFEQDERGLTASELLRLIPEAIRRLK

Ligand information

>2ax3 Chain B (length=8)

SAWAFHAG

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2ax3 Crystal structure of hypothetical protein (tm0922) from THERMOTOGA MARITIMA at 2.27 A resolution
• Resolution: 2.27 Å
• Binding residue (original residue number in PDB): R22 A30 L191 V193 A194 N195
• Binding residue (residue number reindexed from 1): R24 A32 L193 V195 A196 N197

Enzymatic activity

• Enzyme Commision number: 4.2.1.136: ADP-dependent NAD(P)H-hydrate dehydratase.
  5.1.99.6: NAD(P)H-hydrate epimerase.

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016829 lyase activity
• GO:0016836 hydro-lyase activity
• GO:0016853 isomerase activity
• GO:0046872 metal ion binding
• GO:0052855 ADP-dependent NAD(P)H-hydrate dehydratase activity
• GO:0052856 NAD(P)HX epimerase activity

Biological Process

• GO:0046496 nicotinamide nucleotide metabolic process
• GO:0110051 metabolite repair

External links

• PDB: RCSB:2ax3, PDBe:2ax3, PDBj:2ax3
• PDBsum: 2ax3
• UniProt: Q9X024|NNR_THEMA Bifunctional NAD(P)H-hydrate repair enzyme Nnr (Gene Name=nnr)