Structure of PDB 2ask Chain A Binding Site BS01

Receptor Information
>2ask Chain A (length=101) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ARGCRLRSQLVPVRALGLGHRSDELVRFRFCSGSCRRARSPHDLSLASLL
GAGALRPPPGSRPVSQPCCRPTRYEAVSFMDVNSTWRTVDRLSATACGCL
G
Ligand information
Ligand IDSO4
InChIInChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
InChIKeyQAOWNCQODCNURD-UHFFFAOYSA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[O-]S(=O)(=O)[O-]
CACTVS 3.341[O-][S]([O-])(=O)=O
ACDLabs 10.04[O-]S([O-])(=O)=O
FormulaO4 S
NameSULFATE ION
ChEMBL
DrugBankDB14546
ZINC
PDB chain2ask Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2ask Artemin crystal structure reveals insights into heparan sulfate binding.
Resolution1.55 Å
Binding residue
(original residue number in PDB)		S46 R48 R49
Binding residue
(residue number reindexed from 1)		S34 R36 R37
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008083 growth factor activity
GO:0030116 glial cell-derived neurotrophic factor receptor binding
GO:0030971 receptor tyrosine kinase binding

View graph for
Molecular Function
External links
PDB RCSB:2ask, PDBe:2ask, PDBj:2ask
PDBsum2ask
PubMed16734417
UniProtQ5T4W7|ARTN_HUMAN Artemin (Gene Name=ARTN)

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