Structure of PDB 2ash Chain A Binding Site BS01

Receptor Information
>2ash Chain A (length=361) Species: 2336 (Thermotoga maritima) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEFEVKKTFGKARLGVMKLHHGAVETPVFMPVGTNASVKLLTPRDLEEAG
AEIILSNTFHLMLKPGVEIIKLHRGLHNFMGWKRPILTDSGGFQVFSLPK
IRIDDEGVVFRSPIDGSKVFLNPEISMEVQIALGSDICMVFDHCPVADYE
EVKEATERTYRWALRSKKAFKTENQALFGIVQGGIYPDLRRESALQLTSI
GFDGYAIGGLSIGEERSLTLEMTEVTVEFLPEDKPRYFMGGGSPELILEL
VDRGVDMFDSVFPTRIARHGTALTWNGKLNLKASYNKRSLEPVDERCGCY
TCKNFTRSYIHHLFDRGEVLGQILLTIHNINFMISLMKEVRRSIESGTFK
ELKSKVVEVYS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2ash Chain A Residue 400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2ash Crystal structure of Queuine tRNA-ribosyltransferase (EC 2.4.2.29) (tRNA-guanine (tm1561) from THERMOTOGA MARITIMA at 1.90 A resolution
Resolution1.9 Å
Binding residue
(original residue number in PDB)		C299 C301 C304 H330
Binding residue
(residue number reindexed from 1)		C297 C299 C302 H328
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D89 D261 C299 C301 C304 H330
Catalytic site (residue number reindexed from 1) D89 D259 C297 C299 C302 H328
Enzyme Commision number 2.4.2.29: tRNA-guanosine(34) preQ1 transglycosylase.
Gene Ontology
Molecular Function
GO:0008479 tRNA-guanosine(34) queuine transglycosylase activity
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0002099 tRNA wobble guanine modification
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0008616 queuosine biosynthetic process
GO:0101030 tRNA-guanine transglycosylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ash, PDBe:2ash, PDBj:2ash
PDBsum2ash
PubMed
UniProtQ9X1P7|TGT_THEMA Queuine tRNA-ribosyltransferase (Gene Name=tgt)

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