Structure of PDB 2aps Chain A Binding Site BS01

Receptor Information

>2aps Chain A (length=155) Species: 715 (Actinobacillus pleuropneumoniae)

EKLVVQVQQLDPVKGNKDVGTVEITESAYGLVFTPHLHGLAQGLHGFHIH
QNPSCEPKEKDGKLVAGLGAGGHWDPKETKQHGYPWSDNAHLGDLPALFV
EHDGSATNPVLAPRLKKLDEVKGHSLMIHEGGDNHSDHPAPLGGGGPRMA
CGVIK

Ligand information

• Ligand ID: CU
• InChI: InChI=1S/Cu/q+2
• InChIKey: JPVYNHNXODAKFH-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Cu+2]
  CACTVS 3.341: [Cu++]
• Formula: Cu
• Name: COPPER (II) ION
• DrugBank: DB14552
• PDB chain: 2aps Chain A Residue 300

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2aps Cu,Zn superoxide dismutase structure from a microbial pathogen establishes a class with a conserved dimer interface.
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): H48 H50
• Binding residue (residue number reindexed from 1): H36 H38
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.15.1.1: superoxide dismutase.

Gene Ontology

Molecular Function

• GO:0004784 superoxide dismutase activity
• GO:0005507 copper ion binding
• GO:0016209 antioxidant activity
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006801 superoxide metabolic process
• GO:0019430 removal of superoxide radicals
• GO:0098869 cellular oxidant detoxification

Cellular Component

• GO:0042597 periplasmic space

External links

• PDB: RCSB:2aps, PDBe:2aps, PDBj:2aps
• PDBsum: 2aps
• PubMed: 10656823
• UniProt: P24702|SODC_ACTPL Superoxide dismutase [Cu-Zn] (Gene Name=sodC)