Structure of PDB 2amy Chain A Binding Site BS01

Receptor Information
>2amy Chain A (length=240) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PGPALCLFDVDGTLTAPRQKITKEMDDFLQKLRQKIKIGVVGGSDFEKVQ
EQLGNDVVEKYDYVFPENGLVAYKDGKLLCRQNIQSHLGEALIQDLINYC
LSYIAKIKLPKKRGTFIEFRNGMLNVSPIGRSCSQEERIEFYELDKKENI
RQKFVADLRKEFAGKGLTFSIGGQISFDVFPDGWDKRYCLRHVENDGYKT
IYFFGDKTMNDHEIFTDPRTMGYSVTAPEDTRRICELLFS
Ligand information
Ligand IDGLY
InChIInChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChIKeyDHMQDGOQFOQNFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C(=O)O)N
CACTVS 3.341NCC(O)=O
ACDLabs 10.04O=C(O)CN
FormulaC2 H5 N O2
NameGLYCINE
ChEMBLCHEMBL773
DrugBankDB00145
ZINCZINC000004658552
PDB chain2amy Chain A Residue 400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2amy X-Ray Structure of Human Phosphomannomutase 2 (PMM2)
Resolution2.09 Å
Binding residue
(original residue number in PDB)		K202 R225
Binding residue
(residue number reindexed from 1)		K199 R219
Annotation score1
Enzymatic activity
Enzyme Commision number 5.4.2.8: phosphomannomutase.
Gene Ontology
Molecular Function
GO:0004615 phosphomannomutase activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006013 mannose metabolic process
GO:0006486 protein glycosylation
GO:0006487 protein N-linked glycosylation
GO:0009298 GDP-mannose biosynthetic process
GO:0019309 mannose catabolic process
GO:0061728 GDP-mannose biosynthetic process from mannose
GO:0061729 GDP-mannose biosynthetic process from fructose-6-phosphate
GO:0141199 GDP-mannose biosynthetic process from glucose
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043025 neuronal cell body

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2amy, PDBe:2amy, PDBj:2amy
PDBsum2amy
PubMed
UniProtO15305|PMM2_HUMAN Phosphomannomutase 2 (Gene Name=PMM2)

[Back to BioLiP]