Structure of PDB 2amx Chain A Binding Site BS01

Receptor Information

>2amx Chain A (length=364) Species: 5861 (Plasmodium yoelii)

GLVPRGSEIKFLKKEDVQNIDLNGMSKKERYEIWRRIPKVELHCHLDLTF
SAEFFLKWARKYNLQPNMSDDEILDHYLFTKEGKSLAEFIRKAISVSDLY
RDYDFIEDLAKWAVIEKYKEGVVLMEFRYSPTFVSSSYGLDVELIHKAFI
KGIKNATELLNNKIHVALICISDTGHAAASIKHSGDFAIKHKHDFVGFDH
GGREIDLKDHKDVYHSVRDHGLHLTVHAGEDATLPNLNTLYTAINILNVE
RIGHGIRVSESDELIELVKKKDILLEVCPISNLLLNNVKSMDTHPIRKLY
DAGVKVSVNSDDPGMFLSNINDNYEKLYIHLNFTLEEFMIMNNWAFEKSF
VSDDVKSELKALYF

Ligand information

• Ligand ID: CO
• InChI: InChI=1S/Co/q+2
• InChIKey: XLJKHNWPARRRJB-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Co+2]
  CACTVS 3.341: [Co++]
• Formula: Co
• Name: COBALT (II) ION
• DrugBank: DB14205
• PDB chain: 2amx Chain A Residue 1000

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2amx Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.
• Resolution: 2.02 Å
• Binding residue (original residue number in PDB): H55 H57 H239 D323
• Binding residue (residue number reindexed from 1): H43 H45 H227 D311
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): H55 H57 H239 E242 H266 D323
• Catalytic site (residue number reindexed from 1): H43 H45 H227 E230 H254 D311
• Enzyme Commision number: 3.5.4.4: adenosine deaminase.

Gene Ontology

Molecular Function

• GO:0004000 adenosine deaminase activity
• GO:0019239 deaminase activity

Biological Process

• GO:0006154 adenosine catabolic process
• GO:0006166 purine ribonucleoside salvage
• GO:0009168 purine ribonucleoside monophosphate biosynthetic process
• GO:0043103 hypoxanthine salvage
• GO:0046103 inosine biosynthetic process
• GO:0060169 negative regulation of adenosine receptor signaling pathway

Cellular Component

• GO:0005829 cytosol
• GO:0009897 external side of plasma membrane

External links

• PDB: RCSB:2amx, PDBe:2amx, PDBj:2amx
• PDBsum: 2amx
• PubMed: 17125854
• UniProt: Q7RMV2