Structure of PDB 2amq Chain A Binding Site BS01

Receptor Information

>2amq Chain A (length=303)

FRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNP
NYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYK
FVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNI
DYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITL
NVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGP
LSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSG
VTF

Ligand information

>2amq Chain C (length=5) Species: 32630 (synthetic construct)

gAVLa

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2amq Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
• Resolution: 2.3 Å
• Binding residue (original residue number in PDB): H41 F140 G143 C145 H163 H164 M165 E166 P168 D187 Q189 T190
• Binding residue (residue number reindexed from 1): H39 F138 G141 C143 H161 H162 M163 E164 P166 D185 Q187 T188

Enzymatic activity

• Catalytic site (original residue number in PDB): H41 G143 C145
• Catalytic site (residue number reindexed from 1): H39 G141 C143
• Enzyme Commision number: 2.1.1.-
  2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
  2.1.1.57: methyltransferase cap1.
  2.7.7.48: RNA-directed RNA polymerase.
  2.7.7.50: mRNA guanylyltransferase.
  3.1.13.-
  3.4.19.12: ubiquitinyl hydrolase 1.
  3.4.22.-
  3.4.22.69: SARS coronavirus main proteinase.
  3.6.4.12: DNA helicase.
  3.6.4.13: RNA helicase.
  4.6.1.-

Gene Ontology

Molecular Function

• GO:0008233 peptidase activity

Biological Process

• GO:0019082 viral protein processing

External links

• PDB: RCSB:2amq, PDBe:2amq, PDBj:2amq
• PDBsum: 2amq
• PubMed: 16128623
• UniProt: P0C6X7|R1AB_SARS Replicase polyprotein 1ab (Gene Name=rep)