Structure of PDB 2ake Chain A Binding Site BS01

Receptor Information
>2ake Chain A (length=373) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GIDYDKLIVRFGSSKIDKELINRIERATGQRPHHFLRRGIFFSHRDMNQV
LDAYENKKPFYLYTGRGPSSEAMHVGHLIPFIFTKWLQDVFNVPLVIQMT
DDEKYLWKDLTLDQAYSYAVENAKDIIACGFDINKTFIFSDLDYMGMSSG
FYKNVVKIQKHVTFNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQI
FRDRTDIQCLIPCAIDQDPYFRMTRDVAPRIGYPKPALLHSTFFPALQGA
QTKMSASDPNSSIFLTDTAKQIKTKVNKHAFSGGRDTIEEHRQFGGNCDV
DVSFMYLTFFLEDDDKLEQIRKDYTSGAMLTGELKKALIEVLQPLIAEHQ
ARRKEVTDEIVKEFMTPRKLSFD
Ligand information
>2ake Chain B (length=72) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaccucguggcgcaaugguagcgcgucugacuccagaucagaagguugcg
uguucgaaucacgucgggguca
<<<<<<<..<<<.........>>>.<<<<<.......>>>>>.....<<<
<<.......>>>>>>>>>>>>.
Receptor-Ligand Complex Structure
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PDB2ake Structure of human tryptophanyl-tRNA synthetase in complex with tRNA(Trp) reveals the molecular basis of tRNA recognition and specificity
Resolution3.1 Å
Binding residue
(original residue number in PDB)		S272 N373 K374 A376 F377 S378 G380 R381 D382 T383 I384 L426 T427 G428 K431
Binding residue
(residue number reindexed from 1)		S176 N277 K278 A280 F281 S282 G284 R285 D286 T287 I288 L330 T331 G332 K335
Enzymatic activity
Enzyme Commision number 6.1.1.2: tryptophan--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004830 tryptophan-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006436 tryptophanyl-tRNA aminoacylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2ake, PDBe:2ake, PDBj:2ake
PDBsum2ake
PubMed16798914
UniProtP23381|SYWC_HUMAN Tryptophan--tRNA ligase, cytoplasmic (Gene Name=WARS1)

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