Structure of PDB 2aka Chain A Binding Site BS01

Receptor Information

>2aka Chain A (length=764) Species: 44689 (Dictyostelium discoideum)

NPIHDRTSDYHKYLKVKQGDSDLFKLTVSDKRYIWYNPDPKERDSYECGE
IVSETSDSFTFKTVDGQDRQVKKDDANQRNPIKFDGVEDMSELSYLNEPA
VFHNLRVRYNQDLIYTYSGLFLVAVNPFKRIPIYTQEMVDIFKGRRRNEV
APHIFAISDVAYRSMLDDRQNQSLLITGESGAGKTENTKKVIQYLASVAG
RNQANGSGVLEQQILQANPILEAFGNAKTTRNNNSSRFGKFIEIQFNSAG
FISGASIQSYLLEKSRVVFQSETERNYHIFYQLLAGATAEEKKALHLAGP
ESFNYLNQSGCVDIKGVSDSEEFKITRQAMDIVGFSQEEQMSIFKIIAGI
LHLGNIKFEKGAGEGAVLKDKTALNAASTVFGVNPSVLEKALMEPRILAG
RDLVAQHLNVEKSSSSRDALVKALYGRLFLWLVKKINNVLCQERKAYFIG
VLDISGFEIFKVNSFEQLCINYTNEKLQQFFNHHMFKLEQEEYLKEKINW
TFIDFGLDSQATIDLIDGRQPPGILALLDEQSVFPNATDNTLITKLHSHF
SKKNAKYEEPRFSKTEFGVTHYAGQVMYEIQDWLEKNKDPLQQDLELCFK
DSSDNVVTKLFNDPNIASRAKKGANFITVAAQYKEQLASLMATLETTNPH
FVRCIIPNNKQLPAKLEDKVVLDQLRCNGVLEGIRITRKGFPNRIIYADF
VKRYYLLAPNVPRDAEDSQKATDAVLKHLNIDPEQYRFGITKIFFRAGQL
ARIEEAREQRISEI

Ligand information

>2aka Chain L (length=6)

TRLVPR

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2aka Crystal structure of the GTPase domain of rat dynamin 1.
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): I762 S763 E764 I765
• Binding residue (residue number reindexed from 1): I761 S762 E763 I764

Enzymatic activity

• Catalytic site (original residue number in PDB): S181 G182 T186 N233 S236 S237 G457 E459
• Catalytic site (residue number reindexed from 1): S180 G181 T185 N232 S235 S236 G456 E458

Gene Ontology

Molecular Function

• GO:0003774 cytoskeletal motor activity
• GO:0005524 ATP binding
• GO:0051015 actin filament binding

Cellular Component

• GO:0016459 myosin complex

External links

• PDB: RCSB:2aka, PDBe:2aka, PDBj:2aka
• PDBsum: 2aka
• PubMed: 16141317
• UniProt: P08799|MYS2_DICDI Myosin-2 heavy chain (Gene Name=mhcA)