Structure of PDB 2a5l Chain A Binding Site BS01

Receptor Information

>2a5l Chain A (length=171) Species: 287 (Pseudomonas aeruginosa)

SPYILVLYYSRHGATAEMARQIARGVEQGGFEARVRTVPAVSTALYATLE
DLKNCAGLALGSPTRFGNMASPLKYFLDGTSSLWLTGSLVGKPAAVFTST
ASLHGGQETTQLSMLLPLLHHGMLVLGIPYTPYGASHFAGADGKRSLDEH
ELTLCRALGKRLAETAGKLGS

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 2a5l Chain A Residue 199

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2a5l The crystal structure of the Trp repressor binding protein WrbA from Pseudomonas aeruginosa
• Resolution: 1.7 Å
• Binding residue (original residue number in PDB): K195 S198
• Binding residue (residue number reindexed from 1): K168 S171
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.6.5.2: NAD(P)H dehydrogenase (quinone).

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003955 NAD(P)H dehydrogenase (quinone) activity
• GO:0008753 NADPH dehydrogenase (quinone) activity
• GO:0009055 electron transfer activity
• GO:0010181 FMN binding
• GO:0016491 oxidoreductase activity
• GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
• GO:0050136 NADH:ubiquinone reductase (non-electrogenic) activity

Biological Process

• GO:0034599 cellular response to oxidative stress

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:2a5l, PDBe:2a5l, PDBj:2a5l
• PDBsum: 2a5l
• UniProt: Q9I509|NQOR_PSEAE NAD(P)H dehydrogenase (quinone) (Gene Name=PA0949)