Structure of PDB 2a11 Chain A Binding Site BS01

Receptor Information

>2a11 Chain A (length=154) Species: 1773 (Mycobacterium tuberculosis)

IRSRQPLLDALGVDLPDELLSLALTHRSYAYENGGLPTNERLEFLGDAVL
GLTITDALFHRHPDRSEGDLAKLRASVVNTQALADVARRLCAEGLGVHVL
LGRGEANTGGADKSSILADGMESLLGAIYLQHGMEKAREVILRLFGPLLD
AAPT

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 2a11 Chain A Residue 1001

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2a11 Structure of the nuclease domain of ribonuclease III from M. tuberculosis at 2.1 A
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): E44 E123
• Binding residue (residue number reindexed from 1): E43 E122
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.1.26.3: ribonuclease III.

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003725 double-stranded RNA binding
• GO:0004519 endonuclease activity
• GO:0004521 RNA endonuclease activity
• GO:0004525 ribonuclease III activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006364 rRNA processing
• GO:0006396 RNA processing
• GO:0006397 mRNA processing
• GO:0008033 tRNA processing
• GO:0010468 regulation of gene expression

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2a11, PDBe:2a11, PDBj:2a11
• PDBsum: 2a11
• PubMed: 16155207
• UniProt: P9WH03|RNC_MYCTU Ribonuclease 3 (Gene Name=rnc)