Structure of PDB 1zyd Chain A Binding Site BS01

Receptor Information
>1zyd Chain A (length=270) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLRYASDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTIL
SEVMLLASLNHQYVVRYYAAWLERRNFVKKKSTLFIQMEYCENRTLYDLI
HSENLNQQRDEYWRLFRQILEALSYIHSQGIIHRDLKPMNIFIDESRNVK
IGDFGLAKIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIYPFSTGM
ERVNILKKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLL
NSGWLPVKHQDEVIKEALKS
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain1zyd Chain A Residue 306 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1zyd Structural Basis for Autoinhibition and Mutational Activation of Eukaryotic Initiation Factor 2{alpha} Protein Kinase GCN2
Resolution2.75 Å
Binding residue
(original residue number in PDB)		N840 D853
Binding residue
(residue number reindexed from 1)		N140 D153
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D835 K837 N840 D853 T887
Catalytic site (residue number reindexed from 1) D135 K137 N140 D153 T161
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1zyd, PDBe:1zyd, PDBj:1zyd
PDBsum1zyd
PubMed15964839
UniProtP15442|GCN2_YEAST eIF-2-alpha kinase GCN2 (Gene Name=GCN2)

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