Structure of PDB 1zy7 Chain A Binding Site BS01

Receptor Information
>1zy7 Chain A (length=378) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRQPIPSEGLQLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGV
VMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLR
FLYTQLELYLNNKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDAR
IFKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQGERLLTMSCSDKIAR
WNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPP
LYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSAIEVINATTGKDELG
RASRLCKHALYCRWMRVHGKVPSHLLRSKITKPNVYHESKLAAKEYQAAK
ARLFTAFIKAGLGAWVEKPTEQDQFSLT
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1zy7 Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1zy7 Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		H394 C451 C516
Binding residue
(residue number reindexed from 1)		H89 C146 C194
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.4.37: double-stranded RNA adenine deaminase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004000 adenosine deaminase activity
Biological Process
GO:0006396 RNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:1zy7, PDBe:1zy7, PDBj:1zy7
PDBsum1zy7
PubMed16141067
UniProtP78563|RED1_HUMAN Double-stranded RNA-specific editase 1 (Gene Name=ADARB1)

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