Structure of PDB 1zx5 Chain A Binding Site BS01

Receptor Information

>1zx5 Chain A (length=300) Species: 2234 (Archaeoglobus fulgidus)

GMELPSFIFQAQENLVERPWGGEWIALLKGFRQSGIGESWEFSAHTSRPS
TVLVKGQQLSMIELFSKHRDELLGRAAEKFSKFPILVRLIDAASPTQVHV
HPSDKAAESLGEAEGGVESAWLVFNKGKAYAGFKEDVKIEELEEKLKEED
FDFKTLLNTFETTPYDTFVIRPGIPHAGEGLRVLEVSSNSTLAYFFNEND
WEKVKKVLNTKKVEEFEVKGKKGMAETENFGLEVVDVTGTAEIKTGGVMN
ILYAAEGYFILRGKETADLHRGYSCLVPASTDSFTVESERGKIVRIYLKV

Ligand information

• Ligand ID: LFR
• InChI: InChI=1S/C6H12O6/c7-1-3-4(9)5(10)6(11,2-8)12-3/h3-5,7-11H,1-2H2/t3-,4-,5+,6-/m0/s1
• InChIKey: RFSUNEUAIZKAJO-AZGQCCRYSA-N
• SMILES:
  ACDLabs 10.04: OC1C(O)C(OC1(O)CO)CO
  CACTVS 3.341: OC[CH]1O[C](O)(CO)[CH](O)[CH]1O
  OpenEye OEToolkits 1.5.0: C(C1C(C(C(O1)(CO)O)O)O)O
  CACTVS 3.341: OC[C@@H]1O[C@@](O)(CO)[C@H](O)[C@H]1O
  OpenEye OEToolkits 1.5.0: C([C@H]1[C@@H]([C@H]([C@@](O1)(CO)O)O)O)O
• Formula: C6 H12 O6
• Name: beta-L-fructofuranose;
  beta-L-fructose;
  L-fructose;
  fructose;
  BETA-L-FRUCTO-FURANOSE
• DrugBank: DB04173
• PDB chain: 1zx5 Chain A Residue 600

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1zx5 The structure of a putative mannosephosphate isomerase from Archaeoglobus fulgidus
• Resolution: 2.3 Å
• Binding residue (original residue number in PDB): P94 T95 Q96 D149 K153
• Binding residue (residue number reindexed from 1): P95 T96 Q97 D150 K154
• Annotation score: 2

Enzymatic activity

• Enzyme Commision number: 5.3.1.8: mannose-6-phosphate isomerase.

Gene Ontology

Molecular Function

• GO:0004476 mannose-6-phosphate isomerase activity
• GO:0008270 zinc ion binding
• GO:0016853 isomerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0005975 carbohydrate metabolic process

External links

• PDB: RCSB:1zx5, PDBe:1zx5, PDBj:1zx5
• PDBsum: 1zx5
• UniProt: O30200