Structure of PDB 1zt2 Chain A Binding Site BS01

Receptor Information

>1zt2 Chain A (length=327) Species: 2287 (Saccharolobus solfataricus)

TFTLHQGQTNLIKSFFRNYYLNAELELPKDMELREFALQPFGSDTYVRHL
SFSSSEELRDYLVNRNLPLHLFYSSARYQLPSARNMEEKAWMGSDLLFDI
DADHLCKLRSIRFCPVCGNAVVSEKCERDNVETLEYVEMTSECIKRGLEQ
TRNLVEILEDDFGLKPKVYFSGNRGFHVQVDCYGNCALLDSDERKEIAEY
VMGIGVPGYPGGSENAPGWVGRKNRGINGVTIDEQVTIDVKRLIRIPNSL
HGKSGLIVKRVPNLDDFEFNETLSPFTGYTIFLPYITIETEVLGSIIKLN
RGIPIKIKSSIGIYLHLRNLGEVKAYV

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 1zt2 Chain A Residue 999

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1zt2 Structure of the heterodimeric core primase.
• Resolution: 3.33 Å
• Binding residue (original residue number in PDB): C116 C119 C128 D131
• Binding residue (residue number reindexed from 1): C114 C117 C126 D129
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.7.-

Gene Ontology

Molecular Function

• GO:0003896 DNA primase activity
• GO:0005515 protein binding
• GO:0016779 nucleotidyltransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006259 DNA metabolic process
• GO:0006260 DNA replication
• GO:0006269 DNA replication, synthesis of primer

Cellular Component

• GO:0000428 DNA-directed RNA polymerase complex
• GO:1990077 primosome complex

External links

• PDB: RCSB:1zt2, PDBe:1zt2, PDBj:1zt2
• PDBsum: 1zt2
• PubMed: 16273105
• UniProt: Q97Z83|PRIS_SACS2 DNA primase small subunit PriS (Gene Name=priS)