Structure of PDB 1zs0 Chain A Binding Site BS01

Receptor Information

>1zs0 Chain A (length=163) Species: 9606 (Homo sapiens)

MLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFT
RISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAE
ETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSL
PQDDIDGIQAIYG

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 1zs0 Chain A Residue 996

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1zs0 Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates.
• Resolution: 1.56 Å
• Binding residue (original residue number in PDB): D137 G169 I170 G171 D173
• Binding residue (residue number reindexed from 1): D58 G90 I91 G92 D94
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): H197 E198 H201 H207
• Catalytic site (residue number reindexed from 1): H118 E119 H122 H128
• Enzyme Commision number: 3.4.24.34: neutrophil collagenase.

Gene Ontology

Molecular Function

• GO:0004222 metalloendopeptidase activity
• GO:0008237 metallopeptidase activity
• GO:0008270 zinc ion binding

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0031012 extracellular matrix

External links

• PDB: RCSB:1zs0, PDBe:1zs0, PDBj:1zs0
• PDBsum: 1zs0
• PubMed: 16451058
• UniProt: P22894|MMP8_HUMAN Neutrophil collagenase (Gene Name=MMP8)