Structure of PDB 1zm8 Chain A Binding Site BS01

Receptor Information
>1zm8 Chain A (length=239) Species: 1167 (Anabaena sp.) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ISVHLLLGNPSGATPTKLTPDNYLMVKNQYALSYNNSKGTANWVAWQLNS
SWLGNAERQDNFRPDKTLPAGWVRVTPSMYSGSGYARGHIAPSADRTKTT
EDNAATFLMTNMMPQTPDNNRNTWGNLEDYCRELVSQGKELYIVAGPNGS
LGKPLKGKVTVPKSTWKIVVVLDSPGSGLEGITANTRVIAVNIPNDPELN
NDWRAYKVSVDELESLTGYDFLSNVSPNIQTSIESKVDN
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain1zm8 Chain A Residue 276 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1zm8 Structural Insights into the Mechanism of Nuclease A, a beta beta alpha Metal Nuclease from Anabaena.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		D246 E249 E269
Binding residue
(residue number reindexed from 1)		D211 E214 E234
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) H124 N146 N155 E163
Catalytic site (residue number reindexed from 1) H89 N111 N120 E128
Enzyme Commision number 3.1.30.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:1zm8, PDBe:1zm8, PDBj:1zm8
PDBsum1zm8
PubMed15897201
UniProtP38446|NUCA_NOSS1 Nuclease (Gene Name=nucA)

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